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Patients receiving oral morphine prior to treatment with OxyContin should have their daily dose based on the following ratio: 10 mg of oral oxycodone is equivalent to 20 mg of oral morphine. It should be noted that this is a guide to the dose of OxyContin tablets required. Inter-patient variability requires that each patient be carefully titrated to the appropriate dose.

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OxyContin tablets should be taken every 12 hours. The dosage depends on the severity of the pain and the patient’s history of analgesic needs.

Before starting treatment with opioids, a discussion should be held with patients to establish a strategy for stopping treatment with oxycodone to minimize the risk of addiction and drug withdrawal syndrome (see section 4.4).

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Generally, the lowest effective dose for analgesia should be selected. Increasing the severity of pain will require an increase in the dose of OxyContin tablets, using the different strengths of the tablets, alone or in combination, to achieve pain relief. The correct dosage for each patient is one that controls pain and is well tolerated for a full 12 hours.

Patients should be titrated for pain relief unless unmanageable adverse effects prevent this. If higher doses are necessary, increases should be made in 25% to 50% increments. The need for escape medications more than twice a day indicates that the dosage of OxyContin tablets should be increased.

 

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