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The combination oxycodone/paracetamol is a combined opioid/non-opioid pain reliever used to treat moderate to severe acute pain. Percocet contains a combination of acetaminophen and oxycodone. Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of oxycodone.

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You should not use Percocet if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

Percocet is used to relieve moderate to severe pain.

Due of the risks of addiction, abuse, and misuse, even at recommended doses, Percocet is only prescribed when treatment with non-opioid pain relieving medication has not been tolerated or has not provided adequate pain relief.

This medicine can slow or stop your breathing, and may be habit-forming. Use only your prescribed dose, and swallow the pill whole to avoid a potentially fatal dose. Never share Percocet with another person.

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You should not use Percocet if you are allergic to acetaminophen (Tylenol) or oxycodone, or if:

  • you have severe asthma or breathing problems;
  • you have a blockage in your stomach or intestines, including paralytic ileus; or
  • you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

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Some medicines can interact with oxycodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

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To make sure Percocet is safe for you, tell your doctor if you have:

  • any type of breathing problem or lung disease;
  • liver disease, cirrhosis, or if you drink alcohol daily;
  • a history of drug abuse, alcohol addiction, or mental illness;
  • kidney disease, urination problems;
  • problems with your gallbladder, pancreas, thyroid, or adrenal gland;
  • a history of head injury, brain tumor, or seizures; or
  • if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others).

Percocet is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.

If you use oxycodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

Acetaminophen and oxycodone may pass into breast milk and could harm a nursing baby. You should not breast-feed while using this medicine.

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Get emergency medical help if you have signs of an allergic reaction to Percocet: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking Percocet and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

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Like other narcotic medicines, oxycodone can slow your breathing. Death may occur if breathing becomes too weak.

Call your doctor at once if you have:

  • shallow breathing, slow heartbeat;
  • a light-headed feeling, like you might pass out;
  • confusion, unusual thoughts or behavior;
  • seizure (convulsions);
  • problems with urination;
  • infertility, missed menstrual periods;
  • impotence, sexual problems, loss of interest in sex;
  • liver problems – nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low cortisol levels – nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

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Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common Percocet side effects include:

  • headache, drowsiness, tiredness;
  • nausea, vomiting, stomach pain, constipation;
  • blurred vision; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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